P635Cardiac troponin in patients with congestive heart failure treated with cardiac resynchronisation therapy

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Abstract

Elevated concentrations of cardiac Troponin I (cTnI) are frequently observed in patients with acute coronary syndrome (ACS). But its release has recently been studied in conditions other than ACS.

The aim

to assess the relationship between cTnI and inflammatory markers, echo- and electrocardiographic parameters in patients with congestive heart failure (HF) treated with cardiac resynchronization therapy (CRT).

Materials and methods

forty eight patients (mean age 55,2 ± 9,4 years; 88% men) with implanted CRT devices were studied by echocardiography and electrocardiography. Biochemical parameters such as interleukin-6 (IL-6), N-terminal pro-brain natriuretic peptide (NT-proBNP) were assessed. Spearman's correlation was performed to assess the relationship between parameters.

Results

Level of cTnI correlated with NYHA class (r=0,287; p=0,048), left atrial dimension (r=0,376, p=0,008), right ventricular dimension (r=0,326; p= 0,030), left ventricular (LV) systolic and diastolic dimensions (r=0,473; p=0,004; r=0,326; p=0,024), IL-6 level (r=0,365; p=0,011), NT-proBNP level (r=0,350; p=0,015), and negatively correlated with LV ejection fraction (r=-375; p=0,013).

Conclusion

In patients treated with CRT cTnI seams to be a prognostic marker of HF decompensation, taking into account its correlations with functional parameters, NT-proBNP level, inflammatory marker IL-6.

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