Heat shock protein 60 (HSP60) is a mitochondrial protein constitutively expressed in the majority of cells, and its expression up-regulated by a variety of stressors. In heart failure, HSP60 is released from cardiomyocytes; we speculate that increased serum HSP60 (sHSP60) may be related to the severity. We sought to assess the association between sHSP60 and the composite endpoint of death/readmission in patients with acute heart failure (AHF).Methods and Results
132 consecutive patients admitted for AHF. The independent association between sHSP60 and the endpoint was assessed with Cox regression. During a median follow-up of 7 months (IQR:3-14), 35 (26.5%) deaths, 40 (30.3%) readmissions and 65 (49.2%) deaths/readmission were identified. Patients exhibiting the outcome showed higher median sHSP60 values (6.15 ng/ml (8.49) vs 4.71 ng/ml (7.55) p=0.010). A monotonic increase in the incidence of the composite endpoint was observed when moving from lower to higher tertile (4.74, 4.76 and 6.98 per 10 patient-years of follow-up, p for trend < 0.001). After adjusting for established risk factors, only patients in the upper tertile showed an increased risk of death/readmission (HR=2.63, 95% CI:1.29-5.37; p=0.008).Conclusions
In patients with AHF, high sHSP60 was related to a higher risk for subsequent death/readmission for AHF.