P640Serum heat shock protein 60 in acute heart failure: a new biomarker?

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Abstract

Background

Heat shock protein 60 (HSP60) is a mitochondrial protein constitutively expressed in the majority of cells, and its expression up-regulated by a variety of stressors. In heart failure, HSP60 is released from cardiomyocytes; we speculate that increased serum HSP60 (sHSP60) may be related to the severity. We sought to assess the association between sHSP60 and the composite endpoint of death/readmission in patients with acute heart failure (AHF).

Methods and Results

132 consecutive patients admitted for AHF. The independent association between sHSP60 and the endpoint was assessed with Cox regression. During a median follow-up of 7 months (IQR:3-14), 35 (26.5%) deaths, 40 (30.3%) readmissions and 65 (49.2%) deaths/readmission were identified. Patients exhibiting the outcome showed higher median sHSP60 values (6.15 ng/ml (8.49) vs 4.71 ng/ml (7.55) p=0.010). A monotonic increase in the incidence of the composite endpoint was observed when moving from lower to higher tertile (4.74, 4.76 and 6.98 per 10 patient-years of follow-up, p for trend < 0.001). After adjusting for established risk factors, only patients in the upper tertile showed an increased risk of death/readmission (HR=2.63, 95% CI:1.29-5.37; p=0.008).

Conclusions

In patients with AHF, high sHSP60 was related to a higher risk for subsequent death/readmission for AHF.

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