P415Effect of erythrocytes indexes and plasma aldosterone concentration on development of left ventricle hypertrophy in hypertensive men

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Abstract

In the last decade, the number of hypertensive patients continues to increase in the world. Experimental and clinical studies have shown that ischemic or hypertrophied myocardium is more sensitive for a slight decrease in haemoglobin levels than the unmodified myocardium which causes dysfunction of the heart. At the same time there are no studies devoted to the investigation of the relations between erythrocyte homoeostasis indicators (in the frontiers of the normal values) and hypertensive remodelling of LV. Also well known the role of aldosterone in the development of LV remodelling and it the influence on the state of erythrocyte homoeostasis.

The purpose of the study is to identify relationships between PAC, state of erythrocyte homoeostasis and hypertensive remodelling of the heart.

Were enrolled 30 men and 20 women with arterial hypertension 2 grade complicated by HF I-II NYHA functional class. The age of men - 48 (42;52) years, women - 50 (42; 53). Patients with symptomatic hypertension, arrhythmias, diabetes mellitus, haematological disorders were excluded from the study. In all patients were carried determination of mean corpuscular haemoglobin concentration (MCHC, g%) as one of the most informative indicators of the state of erythrocyte homoeostasis and plasma aldosterone concentration (PAC) (pg/ml). Echocardiography was performed according to ASE/EAE recommendations 2005. Statistical significance was defined at the level of methods for p<0,05.

Results of measurements of MCHC and aldosterone levels are shown in Table 1. Performing of regression analysis revealed the combined effect of MCHC and PAC on development of left ventricular hypertrophy in men (ILVmass=-607.7+0.369*PAC+0.6*MCHC; R2= 0,7, p= 0.0016), but not in women (ILVmass=-365+0.1*PAC+0.173*MCHC; R2=0.05, p=0.73).

Thus, in hypertensive men was observed combined effect of MCHC and PAC on the development of left ventricular hypertrophy.

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