P457Effect of changed oxygen free radical on cardiac function of plateau migrants after returning to the low altitude

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Abstract

Objective: To investigate the effect of changed oxygen free radical on cardiac function of plateau migrants after returning to the low altitude.Methods: Serum superoxide dismutase(SOD) and malondialdehyde(MDA) of 923 soldiers who have stayed in the area of high altitude for 110 days were determined by chemical method 1 day and 15 days after returning to the low altitude respectively,and SOD/MDA ratio was calculated. Tei index, left ventricular ejection fraction(LVEF) and left ventricular fractional shortening(LVFS) were measured by color Doppler ultrasonography. Results: Serum SOD and SOD/MDA ratio of those who have exposed shortly in the area of high altitude were significantly reduced while MDA were significantly increased in the early stage after returning to the low altitude compared with those of the control group. Serum SOD and SOD/MDA ratio showed a decreasing trend while MDA showed a rising trend later, and there was still significant difference between them at the 1st day and 15th day after returning to the low altitude (P<0.05). Tei index was significantly higher than that of the control group while LVEF and LVFS were significantly lower than that of the control group at the 1st day after returning to the low altitude (P<0.01). Tei index was significantly reduced while LVEF was significantly increased at the 15th day compared with that of the 1st day after returning to the low altitude (P<0.01). Conclusion: Oxidative injury exists in plateau migrants after returning to the low altitude which has some effects on cardiac function.

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