P745Possible interaction of extremely low frequency electromagnetic fields with atherosclerosis promotion and progression in human, an invitro investigation

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Proposal: Studies of the potential effects of electromagnetic field (EMF) exposure on cardiovascular function have provided some evidence of a possible association. Low density lipoprotein (LDL) modifications are an early step in the promotion and progression of atherosclerosis; the most causes of death in cardiovascular disease (CVD) patients .This study was conducted to evaluate the effects of extremely low frequency (ELF) electromagnetic fields on LDL physicochemical modifications.

Methods: LDL was separated by sequential ultracentrifugation and its susceptibility to oxidation was evaluated by continuous monitoring of conjugated dienes formation, using a spectrophotometer. LDL size and zeta potential is determined by zetasizer instrument.

Results: The results indicated that moderate ELF-EMFs of 2-4 mT can induce the susceptibility of LDL to oxidation and aggregation. Weak ELF-EMFs of 0.125-0.5 mT cause to decrease in LDL zeta potential in a time and dose dependent manner while in moderate ELF-EMFs of 1-4 mT LDL zeta potential was started to increase after the initial decrease at the first hour of exposure.

Conclusions: With regard to the effects of ELF-EMFs on LDL oxidation and aggregation as two important modifications of LDL that involved in the promotion and progression of atherosclerosis, EMFs can be considered as a risk factor in CVD and atherosclerosis.

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