Aberrant frequency of IL-35 producing B cells in colorectal cancer patients

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Abstract

Background

The IL-10 dependent regulatory function of B cells had recently more and more investigated and play important roles in cancer immunity, however, beyond IL-10 whether other inhibitory cytokines play an important role in cancer is lacking. Here, we investigated the role of IL-35 producing B cells in colorectal cancer (CRC).

Methods

Thirty-two healthy controls (HC) and 49 untreated CRC patients were enrolled and the IL-35 producing B cells in the peripheral blood were investigated. Additionally, CD4+CD25+/highCD127low/− regulatory T (Treg) and CD14+HLA-DRlow/− myeloid-derived suppressor cells (MDSCs) were also investigated.

Results

Results show that IL-35 producing B cells were significantly upregulated during the clinical progression of CRC, and negatively correlated with CD3+ T cell, positively correlated with the frequency of CD4+CD25+/highCD127low/− Treg cells and CD14+HLA-DRlow/− MDSCs of these CRC patients.

Conclusions

Together, IL-35 producing B cells were significantly elevated in CRC, indicating this B cell subset might participate in the immune suppression of CRC.

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