Regulation of hematopoiesis by the chemokine system

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HighlightsChemokines play a central role in the maintenance of the hematopoietic niche.The CXC chemokines CXCL12 and CXCL4 retain the progenitors inside the niche.CXCR2 ligands help in the maintenance of the quiescent state of progenitors.CC chemokines inhibit myelopoiesis but are also strong mobilizer of progenitors.Although chemokines are best known for their role in directing cell migration, accumulating evidence indicate their involvement in many other processes. This review focus on the role of chemokines in hematopoiesis with an emphasis on myelopoiesis. Indeed, many chemokine family members are an important component of the cytokine network present in the bone marrow that controls proliferation, retention, and mobilization of hematopoietic progenitors.

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