Lack of association of type 1 diabetes with theIL4Rgene

    loading  Checking for direct PDF access through Ovid

Abstract

Aims/hypothesis

The association between IL4R and type 1 diabetes has been tested in many studies in recent years, with contradictory results. The aim of this study was to re-evaluate the genetic association in type 1 diabetic nuclear families of mixed European background.

Subjects, materials and methods

We genotyped six non-synonymous single-nucleotide polymorphisms (SNPs) of the IL4R gene in 830 nuclear families as specified above, including a French Canadian subset.

Results

No association between type 1 diabetes and any SNP or haplotype was found by the transmission disequilibrium test.

Conclusions/interpretation

Previous positive reports may be due to population stratification as, according to HapMap data, allele frequencies in the IL4R region vary considerably by ethnicity.

Related Topics

    loading  Loading Related Articles