Children with neurodisability have an increased prevalence of respiratory symptoms and morbidity. Several underlying physiological impairments and coexistent problems, like aspiration, make these children vulnerable to respiratory difficulties. The management of these respiratory problems is aimed at improving the quality of life, reducing the risk of exacerbations and further lung damage. This is based on identifying and, where possible, modifying physiological impairments, managing any exacerbating factors and proactive treatment of any complications. Even though increased life expectancy is now possible, an ever-increasing dependence on technology can interfere with quality of life and decisions to escalate to these treatments should be individualised.