PC.53 Concentrated parenteral nutrition solutions and central venous catheter complications in preterm infants

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Abstract

Background

The Standardised, Concentrated with Added Macronutrients Parenteral (SCAMP) nutrition regimen is a method of hyperalimentation shown to improve early head growth in very preterm infants.1 It is possible that increasing the osmolality and lipid/glucose content of neonatal parenteral nutrition (PN) may reduce central venous catheter (CVC) life and/or increases late-onset sepsis (LOS; >72 h) sepsis rates.2 We aimed to compare line life and LOS rates in VPI randomised to receive SCAMP or control PN.

Methods

Control PN was started at birth and infants (<29 weeks, <1200 g) randomised (d2–5) to switch to SCAMP or remain on control PN. CVC, blood culture (BC) and C-reactive protein (CRP) data were collected d1–28.

Results

Infants were randomised to SCAMP (n = 74) and control (n = 76) groups respectively. Survival curve analysis revealed no differences in line life between groups. The CVC-associated infection rates (per 1000 CVC days) were 18.5 (SCAMP) and 23.9 (control). There were no differences in CVC use/type or duration or in positive/negative BC with/without associated CRP rise in SCAMP versus control groups.

Conclusion

Increasing the macronutrient content of a standardised concentrated neonatal PN regimen does not increase CVC complication rates.

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