PC.99 PINC UK (Probiotics in Neonatal Collaboration in UK)

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Abstract

Background

Probiotics have been shown to reduce the risk for definite Necrotising enterocolitis (NEC) and all-cause mortality in very low birth weight babies without any significant adverse effects in > 5000 babies 1–3. Some neonatal units administer probiotics routinely to babies less than 1500g or 32 weeks gestation.

Objective

PINC UK (Probiotics in Neonatal Collaboration in UK) aims to share experiences in the use of probiotics and evaluation of their results in UK neonatal units.

Methods

Retrospective analysis of all babies eligible for probiotics and all babies who received probiotics at Bradford Neonatology, Norfolk and Norwich University Hospitals and Royal Victoria Infirmary Newcastle from September 2011 to December 2013, using data from “Badger” patient information system.

Results

Probiotics were administered to >300 babies with gestation ranging from 23 weeks to term. The lowest birth weight was 438 grams. Probiotics were started on median day 6 of life. Staff and parental acceptance was high, with >85% eligible babies known to have received probiotics. There has not been any confirmed septicaemia associated with the probiotic organisms and total antibiotics usage has not increased. There have not been any significant problems in administration of probiotics and no adverse effects have been noted with the use of probiotics.

Conclusion

Use of probiotics in preterm infants is a safe, low cost, evidence based intervention. We have seen no evidence of probiotic septicaemia. Systematic reviews suggest benefits may accrue to babies receiving them. We hope our experience of administration, and auditing usage will help other units.

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