PFM.09 Reduced glutamate: choline ratio by 1H MRS as a Biomarker for Placental Insufficiency in the Growth Restricted Fetus

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Abstract

Background

Current diagnostic tests for uteroplacental insufficiency are limited. Glutamine and glutamate (Glx) play a vital role in the production of the nucleotides and amino sugars required for cell proliferation in the placenta. Choline (Cho) is a marker of cell turn-over. Proton spectroscopy magnetic resonance spectroscopy (1H MRS) is a safe, non-invasive imaging technique which can detect Glx and Cho. We hypothesised that placenta Glx:Cho ratio could be a useful biomarker of placental function in pregnancies complicated by FGR.

Objective

To undertake a proof-of-concept study assessing placental Glx:Cho ratio in women with healthy pregnancies compared to suspected FGR.

Study design

In vivo placental 1H MRS was performed in 7 pregnancies with FGR and matched to healthy controls. MRI placental volumes were measured. Oxygenation and acid-base balance were determined at birth where possible.

Results

Figure 1 demonstrates an exemplar spectra. The Glx:Cho ratios are shown in Table 1. In each case the Glx/Cho ratio for the FGR placentas are lower than in that of their matched control (p < 0.003).

Conclusion

This preliminary study demonstrates that Glx/Cho ratio may be a potential biomarker of placental insufficiency. Future studies need to establish normal ranges for gestation and explore the clinical implication of a low Glx/Cho ratio for perinatal outcome.

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