PMM.59 Maternal hypothyroxinaemia in pregnancy is associated with altered maternal metabolic parameters

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In euthyroid healthy adults thyroid function is known to be associated with obesity, insulin resistance, glycaemia, and dyslipidaemia. Little is known of similar associations in pregnancy, where maternal subclinical hypothyroidism or hypothyroxinaemia can have a detrimental effect on both mother and fetus.1


To assess the associations between reduced thyroid function (subclinical hypothyroidism/ hypothyroxinaemia), and maternal metabolic parameters in a non-diabetic Caucasian pregnant population.


Detailed anthropometry and fasting biochemistry was obtained on 965 euthyroid Caucasian women with singleton, non-diabetic pregnancies recruited at 28 weeks gestation into the Exeter Family Study of Childhood Health (EFSOCH)2 Thyroid function tests (TSH, FT4 and FT3) and TPO antibodies were measured. Trimester specific reference ranges were identified.(3) We assessed the maternal metabolic parameters (BMI, FPG, triglycerides and insulin resistance (IR)) of those with and without mildly reduced thyroid function.


82 women had hypothyroxinaemia (FT4 < 10.4 mmol/l (<10th centile) and TSH < 3.0 mlU/l) and 133 women (13.9%) had subclinical hypothyroidism (TSH > 3.mlU/l). There was no difference in the metabolic parameters between those with and without subclinical hypothyroidism. Women with hypothyroxinaemia had higher BMI (29.8 (25.3–35.0) vs. 27.4(23.5–31.9), p < 0.001), FPG (4.5(0.4) vs 4.3 (0.4), p = 0.01), triglyceride (2.3 (1.7–3.2) vs 2.0 (1.4–2.8), p < 0.001) and IR (1.6 (0.9–2.7) vs. 1.3 (0.8–2.0), p = 0.001) than those without.


Our study has identified that hypothyoxinaemia is associated with an altered metabolic profile. These findings may have implications for clinical care.

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