Maternal serum pregnancy-associated-plasma-protein-A (PAPP-A) was introduced as a part of combined first trimester trisomy 21 screening (nuchal translucency, PAPP-A and human chorionic gonadotropin) in 2011. We aimed to investigate whether isolated low PAPP-A (< 0.3MoM) was associated with stillbirth, preterm delivery and low birthweight in women booked for delivery in NHS Lothian in 2011.Methods
We retrospectively reviewed case records of women with low PAPP-A level during 2011 (n = 154). Rate of stillbirth, preterm delivery and low birthweight were compared with a control group (n = 9603) who had a normal PAPP-A result, or had opted out of screening. Chi-squared test was used for comparison of rates. Statistical significance was considered at p < 0.05.Results
Rates of stillbirth, preterm delivery and low birthweight were significantly higher in women with low PAPP-A (Table 1).Conclusions
Our results suggest that low PAPP-A at first trimester screening is associated with significantly higher rates of stillbirth, preterm delivery and low birthweight.