Serum gastrin values in patients with familial adenomatous polyposis

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Abstract

PURPOSE:

An evaluation of the importance of gastrin in the colorectal carcinogenesis in patients with familial adenomatous polyposis was conducted.

METHODS:

Blood samples from 168 family members of 26 families were investigated for circulating gastrin. Blood was drawn from 65 affected patients, 66 clinically unaffected first-degree relatives, and 37 spouses.

RESULTS:

We did not find any difference in distribution of serum gastrin among these groups.

CONCLUSION:

Our results seem to exclude gastrin from being relevant in early carcinogenesis in patients with familial adenomatous polyposis.

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