An evaluation of the importance of gastrin in the colorectal carcinogenesis in patients with familial adenomatous polyposis was conducted.METHODS:
Blood samples from 168 family members of 26 families were investigated for circulating gastrin. Blood was drawn from 65 affected patients, 66 clinically unaffected first-degree relatives, and 37 spouses.RESULTS:
We did not find any difference in distribution of serum gastrin among these groups.CONCLUSION:
Our results seem to exclude gastrin from being relevant in early carcinogenesis in patients with familial adenomatous polyposis.