Controlled Dietary Restriction With a Prepackaged Low-Residue Diet Before Colonoscopy Offers Better-Quality Bowel Cleansing and Allows the Use of a Smaller Volume of Purgatives: A Randomized Multicenter Trial

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BACKGROUND:Bowel preparation is burdensome, and less-demanding preparation procedures are needed. Few studies have investigated the effects of low-residue diet and prepackaged low-residue diet in combination with low-volume polyethylene glycol–electrolyte lavage solution during colonoscopy preparation.OBJECTIVE:We compared self-prepared low-residue diets with prepackaged low-residue diets in combination with low-volume polyethylene glycol.DESIGN:This was a single-blinded, 3-arm, multicenter, randomized controlled trial.SETTING:Colonoscopies were conducted in outpatient settings at 3 centers in Taiwan.PATIENTS:The study included 180 patients (age range, 20–75 years) who were scheduled for colonoscopy.INTERVENTIONS:Three groups were compared: group A included self-prepared, 1-day, low-residue diets with a same-day 2.0-L single-dose of polyethylene glycol; group B included prepackaged low-residue diets plus 2.0 L of polyethylene glycol; and group C included prepackaged low-residue diets plus 1.5 L of polyethylene glycol.MAIN OUTCOME MEASURES:The outcome measures were adherence, bowel-cleansing level, and patient satisfaction.RESULTS:One third of the subjects in group A, but none in the prepackaged low-residue diets groups, violated the dietary restrictions. The proportion of right-segment preparation failure was 15.0%, 1.7%, and 6.7% (p = 0.025). Accordingly, treatment B was superior to A (p = 0.008). Among subjects violating the low-residue diets guideline, the right-segment preparation failure rate was 25%. According to a multivariate analysis, low-residue diet compliance (adjusted OR = 6.55 (95% CI, 1.83–23.43)) and BMI were predictors of right-sided preparation adequacy, but the volume of polyethylene glycol ingested was not a predictor. Compared with group A, a greater proportion of subjects in groups B and C reported satisfaction.LIMITATIONS:Patients with high BMI and severe constipation were excluded from this study. This study included only an Asian population.CONCLUSIONS:The prepackaged low-residue diet provides excellent adherence, better bowel cleansing, and a better experience than a self-prepared low-residue diet. With good dietary compliance, 1.5 L of polyethylene glycol provides effective preparation.

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