The aim of this study was to compare portal and splenic blood flows and the liver morphology in hepatosplenic (HS) and hepatointestinal (HI) schistosomiasis. Doppler ultrasound measurements were performed in 48 adult patients with schistosomiasis, according to the criteria of the World Health Organization, and compared with those performed in 20 healthy controls. Portal flow was significantly higher (P < 0.0001) in both HS and HI (2481 ± 1467 and 2159 ± 1446 ml/min, respectively) than in normal individuals (842 ± 322 ml/min). There was no difference in splenic blood flow (822 ± 685 and 458 ± 292 ml/min, respectively) between HS and HI, but these values were significantly higher than those of normal controls (243 ± 94 ml/min). Portal and splenic overflow are found in both the HS and the HI forms of schistosomiasis.