Interleukin 4 –590C/T (rs2243250) Polymorphism Is Associated With Increased Risk of Atopic Dermatitis: Meta-Analysis of Case-Control Studies

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Abstract

Background

Interleukin 4 (IL-4) −590C/T polymorphism has been reported to influence atopic dermatitis (AD) susceptibility, but the results are controversial.

Objective

This meta-analysis was performed to study the association between IL-4 −590C/T polymorphism and AD susceptibility.

Methods

The PubMed, Embase, and China National Knowledge Infrastructure databases were searched. Odds ratios (ORs) with 95% confidence intervals (CIs) were performed to estimate the strength of the association.

Results

Ten studies comprising 923 cases and 1215 controls were included. The overall population revealed significant associations between IL-4 −590C/T polymorphism and AD susceptibility under the allele (OR, 1.19; 95% CI, 1.03–1.38; I2 = 0.0%), recessive (OR, 1.27; 95% CI, 1.002–1.61; I2 = 0.0%), and dominant (OR, 1.33; 95% CI, 1.003–1.76; I2 = 0.0%) models; similar results were found under the allele (OR, 1.19; 95% CI, 1.01–1.39; I2 = 0.0%) and recessive (OR, 1.27; 95% CI, 1.001–1.62; I2 = 0.0%) models after excluding not-in–Hardy-Weinberg equilibrium studies. However, subgroup analyses by ethnicity showed no significant association in Asians or whites. Subgroup analyses by age indicated a significant association in children under the allele (OR, 1.30; 95% CI, 1.06–1.60; I2 = 0.0%) and dominant (OR, 1.42; 95% CI, 1.02–1.97; I2 = 0.0%) models, children in articles with Hardy-Weinberg equilibrium under the allele model (OR, 1.33; 95% CI, 1.05–1.69; I2 = 0.0%), and Asian children under the allele model (OR, 1.41; 95% CI, 1.02–1.95; I2 = 0.0%) but not in white children.

Conclusions

The IL-4 −590C/T polymorphism may contribute to AD susceptibility in the overall population and children, especially for Asian children, but large well-designed studies are warranted to confirm this conclusion.

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