Successful Treatment of Stable Vitiligo by Low-Density Cultured Autologous Melanocyte Transplantation Combined With Narrowband Ultraviolet B Therapy


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Abstract

BACKGROUNDCultured autologous melanocyte transplantation (CMT) is an effective treatment for stable vitiligo, but the current method is time consuming and expensive because of the requirement of a large number of melanocytes.OBJECTIVETo assess the clinical effect of low-density CMT combined with narrowband ultraviolet B (NB-UVB) in treating stable vitiligo.MATERIALS AND METHODSThe authors treated 8 patients with CMT at a low cell density (less than 2.5 × 104 cells/cm2). Among them, 6 patients underwent NB-UVB therapy after CMT.RESULTSAll the 6 patients treated with low-density CMT combined with NB-UVB obtained more than 90% repigmentation at the 1-year follow-up.CONCLUSIONThe authors' data suggest that low-density CMT combined with NB-UVB can be an effective form of surgical treatment for stable vitiligo.

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