Dermatologic Surgery. 44(8):1109–1114, AUG 2018
DOI: 10.1097/DSS.0000000000001527
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PMID: 29664771
Issn Print: 1076-0512
Publication Date: 2018/08/01
Effects of 1,540-nm Fractional Nonablative Erbium and 2,940-nm Fractional Ablative Erbium on p53 Epidermal Expression After 3 months: A Split-Face Interventional Study
Juliano Borges;Luciana Araújo;Rodrigo de Oliveira;Monica Manela-Azulay;
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*Universidade Federal do Rio de Janeiro, Faculdade de Medicina, Serviço de Anatomia Patológica-Brasil, Rio de Janeiro, Brazil;†Universidade Federal do Estado do Rio de Janeiro, Faculdade de Medicina, Serviço de Anatomia Patológica-Brasil, Rio de Janeiro, Brazil
Abstract
Expression of p53 by keratinocytes may be important in the pathogenesis of skin cancer induced by ultraviolet light.We used side-by-side nonablative and ablative erbium fractional laser resurfacing to assess the effects on expression of p53 by facial keratinocytes.Ten female patients (age range, 50–63 years) with Fitzpatrick skin Types I–IV and clinical signs of photoaging underwent erbium fractional laser resurfacing (nonablative, 1,540-nm; ablative, 2,940-nm) on opposite sides of the face. Skin biopsies were obtained before treatment and 3 months after treatment for comparison with control biopsies of face and inner arm, quantifying p53 in immunostained tissue sections.Only ablative (2,940-nm) treatments produced a statistically significant reduction in p53 scoring after 3 months. The histologic appearance of skin after ablative resurfacing more closely resembled inner arm skin (rather than facial skin) of control subjects.Epidermal repopulation with p53-negative keratinocytes through ablative erbium fractional laser resurfacing may diminish the risk of eventual malignancy in photoaged skin.
