Risk Factors for Basal Cell Carcinoma in Men Younger Than 40 Years: A Case–Control Study

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BACKGROUNDBasal cell carcinoma (BCC) is the most common malignancy in the United States and is more prevalent in older populations.OBJECTIVEThe aim of this study was to investigate BCC risk factors in male patients younger than 40 years.MATERIALS AND METHODSA consecutive series of male patients with pathology-proven BCC and younger than 40 years at time of diagnosis were retrospectively identified along with matched controls. Phone interviews were conducted using a structured questionnaire, and differences between patients with and without BCC were investigated.RESULTSA total of 50 patients with BCC and 27 controls were included in this study. Compared with controls, patients with BCC worked outdoor jobs for longer lengths of time (43.2 vs 15.6 months; p = .04), were more likely to have a family history of skin cancer (66% vs 44%; p = .02), and were more likely to use sunscreen heavily after biopsy (p = .02). Patients with multiple BCCs (n = 20) were more likely to have a history of substantial recreational sun exposure (p = .01) than patients with solitary lesions (n = 30).CONCLUSIONThe authors conclude that outdoor sun exposure in patients with underlying genetic susceptibility is the most likely mechanism of BCC formation in young male patients.

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