The construct of homology in the development of behavior is examined using human handedness. Research on the development of hand-use preferences in infants provides some evidence that it may be homologous with adult handedness. Nevertheless, I propose that the construct of homology may not be relevant to the study of human behavioral development. However, other constructs from developmental biology may prove useful in improving developmental psychological research. © 2012 Wiley Periodicals, Inc. Dev Psychobiol 55: 84–91, 2013.