From the Department of Pathology (T.A.), University of Massachusetts Medical Center, Worcester, MA; the Division of Endocrinology and Metabolism (E.K., C.M.) and Omiya Medical Center (N.K., Y.K.), Jichi Medical School Tochigi and Omiya, Japan; the Nagayama Clinic (I.N.), Tochigi, Japan; and the Diabetes Center (Y.U.), Tokyo Women's Medical College, Tokyo, Japan.Address correspondence to Takuya Awata, MD, 2-4-1 Karasugamori, Kokubunji-cho, Shimotsuga-gun, Tochigi-ken, 329-04 Japan.Acknowledgments: we gratefully acknowledge the support of Dr. Arthur A. Like, Dr. Ryoko Hagura, Dr. Tatsuhiko Urakami, Dr. Yasuhiko Iwamoto, and Dr. Yasue Omori.