Association Between Higher Serum Fetuin-A Concentrations and Abnormal Albuminuria in Middle-Aged and Elderly Chinese With Normal Glucose Tolerance


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Abstract

OBJECTIVETo study the association of serum fetuin-A as a potential risk factor with abnormal albuminuria in Chinese individuals with normal glucose tolerance (NGT).RESEARCH DESIGN AND METHODSThe cross-sectional analysis included 607 men and 1,042 women aged 40 or older with NGT.RESULTSWomen with combined microalbuminuria and macroalbuminuria (n = 68) had significantly higher serum fetuin-A concentrations than those with normal albumin excretion (n = 974) (314.3 vs. 280.4 mg/l, P = 0.007). Compared with the lowest quartile, the highest quartile of serum fetuin-A had 40% increased risk of abnormal albuminuria after the multiple adjustments in women (Pfor trend = 0.02). However, the associations were not detected in men.CONCLUSIONSHigher serum fetuin-A was associated with abnormal albuminuria independent of BMI, waist circumference, homeostasis model assessment of insulin resistance, blood pressure, and other determinants of albuminuria in middle-aged and elderly Chinese women with NGT.

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