Associations Between Concentrations of Vitamin D and Concentrations of Insulin, Glucose, and HbA1c Among Adolescents in the United States


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Abstract

OBJECTIVEOur objective was to examine the associations between concentrations of vitamin D and concentrations of insulin, glucose, and HbA1c in a nationally representative sample of adolescents in the U.S.RESEARCH DESIGN AND METHODSWe used data for 1,941 adolescents, aged 12–17 years, who participated in the National Health and Nutrition Examination Survey between 2001 and 2006.RESULTSAdjusted concentrations of insulin were ~24% lower among male subjects with a concentration of vitamin D ≥75 nmol/L than among male subjects with a concentration of vitamin D <50 nmol/L (P = 0.003). Concentrations of vitamin D were inversely associated with concentrations of glucose only among Mexican American male subjects (P = 0.007). No significant associations between concentrations of vitamin D and HbA1c were detected.CONCLUSIONSOur results support an inverse association between concentrations of vitamin D and insulin primarily in adolescent male subjects.

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