Intraductal tubulopapillary neoplasm of the pancreas suspected by endoscopic ultrasonography–fine-needle aspiration cytology: Report of a case confirmed by surgical specimen histology

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Intraductal tubulopapillary neoplasm (ITPN) of the pancreas is rare compared with intraductal papillary mucinous neoplasm (IPMN). These entities are distinguished by endoscopic ultrasonography (EUS)–fine-needle aspiration cytology (FNAC) on the basis of mucin production and the presence of a tubular or papillary growth pattern. In addition, there are several tumor types that should be distinguished from ITPN, such as solid pseudopapillary neoplasm, acinar cell carcinoma, and pancreatic neuroendocrine tumor. Herein, a case of an 80-year-old man with ITPN, which was suspected based on EUS-FNAC findings at the time of review and confirmed by histological examination of the surgically resected specimen, has been presented. There have only been three reported cases that included the cytology of ITPN in the English language literature, all of which propose diagnostic features of ITPN based on cytological specimens. Here, a previously undescribed diagnostic feature of ITPN revealed by EUS–FNAC—tubules in contact with fibrovascular structures—correlated well with the histological findings of the surgically resected specimen, has been shown. Diagn. Cytopathol. 2015;43:1003–1006. © 2015 Wiley Periodicals, Inc.

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