The efficacy and prognosis of balloon dilation (EBD) therapy for various benign pyloroduodenal strictures was investigated. Subjects were 19 patients; nine with Crohn's disease, six with a duodenal ulcer, and four patients with duodenal second part strictures. Endoscopic EBD was started with through-the-scope (TTS) balloon with the primary endpoint being the endoscope passing through the lesions. All except one of the patients attained primary success from the EBD session. Long-term prognosis was good for 11 of 15 with pyloric channel stenosis (73.3%), and excluded patients with second part stenosis during the observation period (average = 5.3 years). Prognosis for EBD for benign pyloroduodenal stricture is favorable and this procedure is recommended for such patients.