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The aim of this study was to investigate the effects of Kinesio Taping (KT) on the body functions and activity of children with unilateral spastic cerebral palsy (CP).This study was designed as a single-blind, randomized, controlled trial. Thirty children with unilateral spastic CP were randomized and split equally between the KT group (eight males, seven females; mean age 9y [SD 2y 3mo] range 7–12y) and the control group (seven males, eight females; mean age 9y 7mo [SD 3y 4mo] range 7–14y) receiving usual care. All participants were evaluated with the Functional Independence Measure for Children (WeeFIM), the Bruininks–Oseretsky Test of Motor Proficiency (BOTMP), the Gross Motor Function Measure (GMFM), short-term muscle power, agility and functional muscle strength tests. Wilcoxon signed-rank and Mann–Whitney U tests were used to evaluate within and between-group differences respectively. The level of significance was accepted as p<0.05.There were significant differences in muscle power sprint (p=0.003), lateral step-up test right (p=0.016), sit to stand (p=0.018), attain stand through half knee right (p=0.003), BOTMP Gross scores (p=0.019), and WeeFIM total (p=0.003) and self-care scores (p=0.022) between the groups (p<0.05).Kinesio Taping is a promising additional approach to increase proprioceptive feedback and improve physical fitness, gross motor function, and activities of daily living in children with CP.Insight into the effectiveness of Kinesio Taping on body functions and activity in children with unilateral CP.It shows that Kinesio Taping is effective on performance-related physical fitness, gross motor function, and activities of daily living.This article is commented on by Iosa on pages 11–12 of this issue.