[Black Down-Pointing Triangle] Empagliflozin, diabetes and outcomes

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The prevalence of type 2 diabetes is rising, and in 2015 more than 5% of adults in the UK were affected by this condition.1,2 Management of type 2 diabetes includes encouraging lifestyle changes (increased exercise, modification of diet and smoking cessation) alongside the provision of medication to minimise long-term complications and manage blood sugar control while avoiding unwanted effects of drug treatment.3 Of particular importance, people with type 2 diabetes are at increased risk of cardiovascular disease, and therefore the aims of treatment also include modification of associated risk factors.2-5

[Black Down-Pointing Triangle] Empagliflozin (Jardiance-Boehringer Ingelheim) is the third sodium-glucose co-transporter-2 (SGLT2) inhibitor licensed for use in the UK. It was launched in August 2014, and acts in a similar way to the other SGLT2 inhibitors, [Black Down-Pointing Triangle] dapagliflozin and [Black Down-Pointing Triangle] canagliflozin, by inhibiting renal glucose resorption and promoting glycosuria.6 It is indicated for the treatment of type 2 diabetes in adults to improve glycaemic control, as monotherapy when metformin cannot be used, and in combination with other glucose-lowering drugs including insulin. Here we review the evidence for empagliflozin and discuss the results of a recent study that assessed cardiovascular outcomes.

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