Management of Newly Diagnosed Acute Myeloid Leukemia in the Elderly: Current Strategies and Future Directions

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Abstract

Key Points

Acute myeloid leukemia affects predominantly older adults and, although the general prognosis is relatively poor, the majority of patients benefit from treatment.

Key Points

Treatment with intensive chemotherapy is appropriate in fit older adults, and allogeneic transplant is increasingly a valid post-remission treatment strategy in this group.

Key Points

Several novel agents are currently in development and may improve outcomes for less fit older adults, either alone or in combination with hypomethylating agents and low-dose cytarabine.

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