Age-Related Changes in Hepatic Function: An Update on Implications for Drug Therapy

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Abstract

Key Points

Age-related change in hepatic function causes much of the variability in older people's responses to medication.

Key Points

In the absence of randomised controlled trials supporting titration of doses in older people, an appreciation of the fundamental pharmacokinetic changes related to hepatic drug clearance and protein binding can guide clinicians in their decision making concerning dose adjustment.

Key Points

A decline in the ability of the liver to inactivate toxins may contribute to a proinflammatory state in which frailty can develop.

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