Methotrexate in asthma: a limited role at present

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IN BRIEFCurrent data do not support an extensive role for methotrexate in asthmatic patients. The drug has been shown to reduce oral corticosteroid requirements in some, but not all, trials in severely affected asthmatic patients.Adverse effects observed in these trials have generally been mild, but serious adverse effects of methotrexate involving the lungs, liver and blood remain a concern.Thus, methotrexate may be considered as an adjunct to corticosteroids in patients who require regular administration of oral prednisolone in dosages of ≥ 10 mg/day (or equivalent dosages of other systemic steroids), but who either continue to deteriorate or are unable to tolerate corticosteroid-related adverse effects.

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