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Piperacillin/tazobactam has a broad spectrum of activity and is worthy of consideration in patients with polymicrobial infections.Tazobactam successfully protects piperacillin from inactivation by a range of β-lactamases. However, selective activity against class I β-lactamases is cause for concern, particularly in nosocomial infections.Piperacillin/tazobactam appears as effective as comparator agents in moderate to severe intra-abdominal, skin and soft tissue, and respiratory tract infections. In more severe infections, the addition of an aminoglycoside may be required.Piperacillin/tazobactam has also been effective in the empirical treatment of neutropenic patients with unexplained fever, when combined with an aminoglycoside. However, additional coverage against Gram-positive infections has been required frequently in these patients.The tolerability profile of piperacillin/tazobactam appears typical of other penicillins.