Clinical considerations are paramount when prescribing metoprolol

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IN BRIEFMetoprolol is a β1-blocker that has demonstrated efficacy in a range of cardiovascular indications. Pharmacoeconomic and quality-of-life data extend these observations in some situations, as follows.In one study, metoprolol appeared to be cost effective compared with thiazide diuretics in men with hypertension. However, the clinical relevance of these results is questionable, since the analysis was based on controversial data from a trial utilising relatively high dosages of thiazide diuretics.The effects of metoprolol on quality of life are similar to those of atenolol, but may be inferior to those of diltiazem and lisinopril, in hypertensive patients.In patients who have experienced an acute myocardial infarction, metoprolol offers cost savings and improvements in quality of life compared with placebo.Quality-of-life data support the use of metoprolol in patients with idiopathic dilated cardiomyopathy.

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