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Lyme disease vaccine appears to be the most effective management option for the prevention of Lyme disease. Although administration of the adjuvanted formulation of Lyme disease vaccine (LYMErix™) is recommended according to a 12-month vaccination schedule, a 6-month schedule appears to induce similar immunogenicity. It provides effective protection against Lyme disease in approximately 80% of vaccinated adults and, on the basis of preliminary data, it may also have a place in the prevention of Lyme disease in children <15 years of age.However, booster doses are necessary to ensure protective antibody levels are maintained for longer than 1 or 2 Lyme disease seasons. In view of its high protective efficacy and good tolerability profile, Lyme disease vaccine represents a promising agent for the prevention of Lyme disease.