Avoid even normal consumption of grapefruit juice if potential interaction with oral cardiovascular drugs

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Grapefruit juice, which inhibits gastrointestinal cytochrome P450 3A4 enzymes and the drug transporter P-glycoprotein, interacts with several oral cardiovascular drugs. Consumption of as little as a glassful of the juice may result in a clinically relevant pharmacokinetic interaction. Therefore, it is prudent to avoid consumption of grapefruit juice during pharmacotherapy with drugs that are expected to interact with the juice.

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