Stabilise atypical antipsychotic therapy in patients with comorbid schizophrenia and obsessive compulsive disorder, then add other agents if necessary

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Schizophrenic patients often also have obsessive compulsive disorder (OCD). In the absence of evidence-based data, treatment guidelines suggest monotherapy with atypical antipsychotics or combination therapy with atypical or typical antipsychotics plus selective serotonin reuptake inhibitors or clomipramine. Drug-induced exacerbations of obsessive-compulsive symptoms have been associated with antipsychotic therapy. Generally, only antipsychotic-stabilised schizophrenic patients should receive anti-obsessive agents for the treatment of OCD.

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