Pharmacological management of severe acute agitation generally involves rapid tranquillisation with parenteral antipsychotics

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Patients with a variety of medical or psychiatric conditions may experience acute agitation. In the management of severe acute agitation, the patients should be quickly calmed by rapid tranquillisation, in order to decrease dangerous behaviour and allow treatment of the underlying condition. The most widely currently used agents are intramuscular haloperidol and lorazepam, which are often given in combination. Recently available intramuscular formulations of the atypical antipsychotics olanzapine and ziprasidone are well tolerated, effective, and facilitate transition to oral therapy

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