α-Adrenoceptor antagonists best choice for initial treatment of lower urinary tract symptoms related to benign prostatic hyperplasia


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Abstract

First-line treatment of lower urinary tract symptoms related to benign prostatic hyperplasia (LUTS/BPH) is with α-adrenoceptor antagonists; the newer agents (alfuzosin and tamsulosin) have a better tolerability profile than the older drugs (doxazosin and terazosin). 5α-Reductase inhibitors (finasteride and dutasteride) are considered second-line treatment of LUTS/BPH. Combination therapy with an α-adrenoceptor antagonist plus a 5α-reductase inhibitor appears more effective than monotherapy only after long-term use.

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