Hormone replacement therapy (HRT) with drospirenone offers the additional benefit of blood pressure reduction in postmenopausal women

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The risk of cardiovascular (CV) events in postmenopausal women increases with the use of hormone replacement therapy. Drospirenone, a unique synthetic progestogen, is effective in treating menopausal symptoms and also has potent antimineralocorticoid effects that counteract the sodium- and fluid-retaining effects of estrogen. In clinical studies, drospirenone reduced blood pressure in postmenopausal women with hypertension, which could potentially lead to reductions in some CV risks

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