Prevent aortic complications in patients with Marfan's syndrome by targeting the underlying histological and haemodynamic abnormalities


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Abstract

Marfan's syndrome, a genetic disorder of the connective tissue, is associated with serious cardiovascular complications, including aortic dilation leading to aortic dissection, rupture or insufficiency. β-adrenoceptor antagonists, calcium channel antagonists and ACE inhibitors are used in the prevention of aortic complications in patients with Marfan's syndrome, as these agents target the underlying histological and haemodynamic abnormalities

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