Persistence is the key to treating nonpsychotic major depressive disorder in elderly patients

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Response to initial antidepressant pharmacotherapy is only achieved in ≊50% of elderly patients with nonpsychotic major depressive disorder. When response to persistent initial treatment is incomplete, switching to another antidepressant agent is just as effective as augmenting therapy with another agent, while also being less expensive, safer and associated with better compliance. Combination therapy should be reserved for repeat nonresponders to monotherapy. Nonpharmacological measures also play an important role

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