Pathological laughing and crying may be caused by many neurological disorders and is highly responsive to treatment


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Abstract

Pathological laughing and crying (PLC), which is characterized by brief, intense, frequent episodes of uncontrollable laughing and/or crying, may be due to a wide variety of neurological disorders. Selective serotonin reuptake inhibitors (SSRIs) are recommended as first-line therapy for PLC. If SSRIs are poorly tolerated or ineffective, other treatment options include tricyclic antidepressants, novel antidepressants, dopaminergic agents or uncompetitive NMDA receptor antagonists

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