Sublingual asenapine: a guide to its use in acute mania in adults with bipolar I disorder

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Monotherapy or adjunctive therapy with sublingual asenapine improves acute mania in adults with bipolar I disorder. At week 3 of randomized, double-blind trials in adults with manic or mixed episodes associated with bipolar I disorder, monotherapy or adjunctive therapy with flexible-dose sublingual asenapine improved Young Mania Rating Scale total scores to a significantly greater extent than placebo. Sublingual asenapine is generally well tolerated and appears to have a generally favourable metabolic/endocrine profile.

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