Switch to another drug or try adjunctive therapy in patients with treatment-resistant obsessive-compulsive disorder

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Resistance to pharmacological treatment is common in patients with obsessive-compulsive disorder. If increasing the dosage provides no benefit in patients responding inadequately to selective serotonin reuptake inhibitor (SSRI) therapy, switching to an alternative SSRI or clomipramine is recommended. Subsequent pharmacological options include augmentation with an antipsychotic agent, or the use of an antidepressant of another class or that is administered intravenously.

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