Consider topical therapies when osteoarthritis is in only a few superficial joints

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Topical therapies (e.g. NSAIDs and capsaicin) may be a more appropriate approach than oral analgesics (e.g. paracetamol [acetaminophen] or NSAIDs) in patients with mild to moderate osteoarthritis in a few superficial joints. This is because systemic drug exposure is limited with topical formulations, which minimizes the likelihood of adverse events and drug-drug interactions.

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