Assess the evidence and prepare plan of action prior to intentional rechallenge with drugs suspected of causing an adverse reaction

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Intentional rechallenge of a drug suspected of being a possible cause of an adverse reaction occurs when a healthcare provider decides that the benefit of readministration of the drug will outweigh its risk. Before attempting rechallenge, healthcare professionals should examine the best clinical evidence to determine the benefit/risk balance of the suspected causative drug versus other available treatments (or no treatment), assess the risk of rechallenge, prepare a plan of action to mitigate the risk of rechallenge, and provide appropriate information to, and obtain consent from, patients or caregivers.

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