Treat cutaneous lupus erythematosus primarily with topical corticosteroids and systemic antimalarials

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Cutaneous lupus erythematosus (CLE) includes a variety of skin lesions specific for lupus erythematosus that are classified as chronic, subacute and acute. Generally, the management of patients with chronic or subacute CLE involves the use of broad-spectrum sunscreens and local treatment with topical or intralesional corticosteroids. Systemic treatments are usually indicated when topical or intralesional corticosteroids fail to control CLE. In patients with acute CLE, systemic immunosuppressive agents are needed to manage the underlying disease activity.

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