Aminoglycoside use in critically ill patients requires careful regimen planning and drug monitoring to avoid nephrotoxicity

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Aminoglycoside therapy has many desirable advantages for use in critically ill patients with severe sepsis or septic shock. However, these patients are at greater risk of developing drug-induced nephrotoxicity. The use of aminoglycosides in such patients requires special considerations with regard to dosage regimens and therapeutic drug monitoring.

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