Clozapine oral suspension (Versacloz™): a guide to its use in the USA

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Abstract

Clozapine, an atypical antipsychotic, has recently become available in the USA in the form of an oral suspension (Versacloz™). The oral suspension formulation has several potential advantages over traditional tablet formulations. The efficacy of clozapine in the treatment of treatment-resistant schizophrenia, and in reducing suicidal behavior in patients with schizophrenia or schizoaffective disorder, is well-established. Although its use has been limited by its association with serious hematological toxicity, it is considered the antipsychotic of choice in patients with treatment-resistant schizophrenia, and is also of benefit in reducing suicidal behavior in patients with schizophrenia or schizoaffective disorder.

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